Researchers in the fields of oncology, immunology and hematology need benign nodes and normal adjacent human tissue samples from the same disease to use as controls. The following are three research applications for employing normal tissue samples:
Tissue Samples in Evaluating New Diagnostic Tests
Large biotech companies use diagnostic tests for the measuring and detection of cancer variables. In order to do this, they need to pair the effect of the test on diseased human tissue samples versus adjacent normal samples. Some examples of diseased samples that need to be tested against normal samples are breast cancer, melanoma, and lung cancer human tissue samples.
Tissue Samples for Research in Tumor-Associated Antigens
In a study published in the Journal of Translational Medicine, researchers needed to find which antigens associated with tumors would be useful for managing colon cancer. They used human tumor tissue samples and adjacent normal tissue samples in the study to develop their findings.
Tissue Samples in Genomics
Genomics is becoming an increasingly popular area of study because scientists are looking to understand the molecular causes of many diseases, such as cancer. Advanced sequencing technology is frequently used to generate lots of data on the genetic changes that cause malignant tumors.
references
http://www.conversantbio.com/blog/5-research-applications-for-normal-tissue-samples
